1H-Imidazol-4(5H)-ones and thiazol-4(5H)-ones as emerging pronucleophiles in asymmetric catalysis
نویسندگان
چکیده
Asymmetric catalysis represents a very powerful tool for the synthesis of enantiopure compounds. In this context the main focus has been directed not only to the search for new efficient chiral catalysts, but also to the development of efficient pronucleophiles. This review highlights the utility and first examples of 1H-imidazol-4(5H)-ones and thiazol-4(5H)-ones as pronucleophiles in catalytic asymmetric reactions.
منابع مشابه
Asymmetric [4 2] annulation of 5H-thiazol-4-ones with a chiral dipeptide-based Brønsted base catalyst
Versatile synthetic strategies that access diverse chemical substrates in a highly chemoand stereoselective manner are crucial but demanding. Construction of chiral molecules with multiple (hetero)quaternary carbon stereocenters in a single fashion is a particularly significant challenge, with important applications in the synthesis of a range of bioactive compounds containing the 1,4-sulfur br...
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